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SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?

SULT1A1, a member of sulfotransferase superfamily, is a drug and hormone metabolizing enzyme involved in the metabolism of a variety of potential mammary carcinogens of endogenous and exogenous origin. Interestingly, the metabolic activity of SULT1A1 can be affected by variations in gene copy number...

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Autores principales: Palli, Domenico, Rizzolo, Piera, Zanna, Ines, Silvestri, Valentina, Saieva, Calogero, Falchetti, Mario, Navazio, Anna Sara, Graziano, Veronica, Masala, Giovanna, Bianchi, Simonetta, Russo, Antonio, Tommasi, Stefania, Ottini, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822812/
https://www.ncbi.nlm.nih.gov/pubmed/23711090
http://dx.doi.org/10.1111/jcmm.12043
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author Palli, Domenico
Rizzolo, Piera
Zanna, Ines
Silvestri, Valentina
Saieva, Calogero
Falchetti, Mario
Navazio, Anna Sara
Graziano, Veronica
Masala, Giovanna
Bianchi, Simonetta
Russo, Antonio
Tommasi, Stefania
Ottini, Laura
author_facet Palli, Domenico
Rizzolo, Piera
Zanna, Ines
Silvestri, Valentina
Saieva, Calogero
Falchetti, Mario
Navazio, Anna Sara
Graziano, Veronica
Masala, Giovanna
Bianchi, Simonetta
Russo, Antonio
Tommasi, Stefania
Ottini, Laura
author_sort Palli, Domenico
collection PubMed
description SULT1A1, a member of sulfotransferase superfamily, is a drug and hormone metabolizing enzyme involved in the metabolism of a variety of potential mammary carcinogens of endogenous and exogenous origin. Interestingly, the metabolic activity of SULT1A1 can be affected by variations in gene copy number. Male Breast Cancer (MBC) is a rare disease and less investigated disease compared to female BC (FBC). As in FBC, the concurrent effects of genetic risk factors, particularly BRCA2 mutations, increased exposure to estrogens and environmental carcinogens play a relevant role in MBC. By quantitative real-time PCR with TaqMan probes, we investigated the presence of SULT1A1 gene copy number variations (CNVs) in a series of 72 MBCs. SULT1A1 gene deletion was observed in 10 of the 72 MBCs (13.9%). In a multivariate analysis association between BRCA2 mutation and SULT1A1 gene deletion emerged (p = 0.0005). Based on the evidence that the level of SULT1A1 enzyme activity is correlated with CNV, our data suggest that in male breast tumors SULT1A1 activity may be decreased. Thus, it can be hypothesized that in a proportion of MBCs, particularly in BRCA2-associated MBCs, the level of estrogens and environmental carcinogens exposure might be increased suggesting a link between gene and environmental exposure in the pathogenesis of MBC.
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spelling pubmed-38228122014-12-03 SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures? Palli, Domenico Rizzolo, Piera Zanna, Ines Silvestri, Valentina Saieva, Calogero Falchetti, Mario Navazio, Anna Sara Graziano, Veronica Masala, Giovanna Bianchi, Simonetta Russo, Antonio Tommasi, Stefania Ottini, Laura J Cell Mol Med Short Communication SULT1A1, a member of sulfotransferase superfamily, is a drug and hormone metabolizing enzyme involved in the metabolism of a variety of potential mammary carcinogens of endogenous and exogenous origin. Interestingly, the metabolic activity of SULT1A1 can be affected by variations in gene copy number. Male Breast Cancer (MBC) is a rare disease and less investigated disease compared to female BC (FBC). As in FBC, the concurrent effects of genetic risk factors, particularly BRCA2 mutations, increased exposure to estrogens and environmental carcinogens play a relevant role in MBC. By quantitative real-time PCR with TaqMan probes, we investigated the presence of SULT1A1 gene copy number variations (CNVs) in a series of 72 MBCs. SULT1A1 gene deletion was observed in 10 of the 72 MBCs (13.9%). In a multivariate analysis association between BRCA2 mutation and SULT1A1 gene deletion emerged (p = 0.0005). Based on the evidence that the level of SULT1A1 enzyme activity is correlated with CNV, our data suggest that in male breast tumors SULT1A1 activity may be decreased. Thus, it can be hypothesized that in a proportion of MBCs, particularly in BRCA2-associated MBCs, the level of estrogens and environmental carcinogens exposure might be increased suggesting a link between gene and environmental exposure in the pathogenesis of MBC. Blackwell Publishing Ltd 2013-05 2013-05-27 /pmc/articles/PMC3822812/ /pubmed/23711090 http://dx.doi.org/10.1111/jcmm.12043 Text en Copyright © 2013 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Short Communication
Palli, Domenico
Rizzolo, Piera
Zanna, Ines
Silvestri, Valentina
Saieva, Calogero
Falchetti, Mario
Navazio, Anna Sara
Graziano, Veronica
Masala, Giovanna
Bianchi, Simonetta
Russo, Antonio
Tommasi, Stefania
Ottini, Laura
SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?
title SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?
title_full SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?
title_fullStr SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?
title_full_unstemmed SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?
title_short SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?
title_sort sult1a1 gene deletion in brca2-associated male breast cancer: a link between genes and environmental exposures?
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822812/
https://www.ncbi.nlm.nih.gov/pubmed/23711090
http://dx.doi.org/10.1111/jcmm.12043
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