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P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis

In the present study, we show that overexpression of the G-protein-coupled receptor (GPCR)-associated sorting protein p60TRP (transcription regulator protein) in neural stem cells (NSCs) and in a transgenic mouse model modulates the phosphorylation and proteolytic processing of amyloid precursor pro...

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Detalles Bibliográficos
Autores principales: Mishra, Manisha, Heese, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822957/
https://www.ncbi.nlm.nih.gov/pubmed/21199326
http://dx.doi.org/10.1111/j.1582-4934.2010.01248.x