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Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity
The Neurofibromatosis 2 (NF2) gene product merlin is a tumour suppressor, which in addition to inhibiting cell proliferation regulates cell morphology. The morphogenic properties of merlin may play a role in tumour suppression, as patient-derived tumour cells demonstrate cytoskeletal abnormalities....
Autores principales: | Laulajainen, Minja, Melikova, Maria, Muranen, Taru, Carpén, Olli, Grönholm, Mikaela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822986/ https://www.ncbi.nlm.nih.gov/pubmed/22325036 http://dx.doi.org/10.1111/j.1582-4934.2012.01525.x |
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