HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

The present study identified a novel mechanism of induction of apoptosis in glioblastoma cells by scriptaid – a histone deacetylase (HDAC) inhibitor. Scriptaid reduced glioma cell viability by increasing Jun N-terminal kinase (JNK) activation. Although scriptaid induced activation of both p38MAPK an...

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Detalles Bibliográficos
Autores principales: Sharma, Vivek, Koul, Nitin, Joseph, Christy, Dixit, Deobrat, Ghosh, Sadashib, Sen, Ellora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823006/
https://www.ncbi.nlm.nih.gov/pubmed/19583803
http://dx.doi.org/10.1111/j.1582-4934.2009.00844.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823006/
https://www.ncbi.nlm.nih.gov/pubmed/19583803
http://dx.doi.org/10.1111/j.1582-4934.2009.00844.x

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