Evaluation of nasal epithelium sampling as a tool in the preclinical development of siRNA-based therapeutics for asthma

The development of siRNA-based asthma therapeutics is currently hampered by a paucity of relevant biomarkers and the need to ascertain tissue-specific gene targeting in the context of active disease. Epithelial STAT6 expression is fundamental to asthma pathogenesis in which inflammatory changes are...

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Detalles Bibliográficos
Autores principales: Healey, Gareth D, Evans, Neil, Hopkin, Julian M, Davies, Gwyneth, Walker, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823017/
https://www.ncbi.nlm.nih.gov/pubmed/23402658
http://dx.doi.org/10.1111/jcmm.12014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823017/
https://www.ncbi.nlm.nih.gov/pubmed/23402658
http://dx.doi.org/10.1111/jcmm.12014

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