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Evaluation of nasal epithelium sampling as a tool in the preclinical development of siRNA-based therapeutics for asthma
The development of siRNA-based asthma therapeutics is currently hampered by a paucity of relevant biomarkers and the need to ascertain tissue-specific gene targeting in the context of active disease. Epithelial STAT6 expression is fundamental to asthma pathogenesis in which inflammatory changes are...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823017/ https://www.ncbi.nlm.nih.gov/pubmed/23402658 http://dx.doi.org/10.1111/jcmm.12014 |