Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3

The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to the proximal promoter. To identify the HDACs inv...

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Detalles Bibliográficos
Autores principales: Pufahl, Laura, Katryniok, Careen, Schnur, Nicole, Sorg, Bernd L, Metzner, Julia, Grez, Manuel, Steinhilber, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823215/
https://www.ncbi.nlm.nih.gov/pubmed/21883892
http://dx.doi.org/10.1111/j.1582-4934.2011.01420.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823215/
https://www.ncbi.nlm.nih.gov/pubmed/21883892
http://dx.doi.org/10.1111/j.1582-4934.2011.01420.x

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