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Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons
Decreased rRNA synthesis and nucleolar disruption, known as nucleolar stress, are primary signs of cellular stress associated with aging and neurodegenerative disorders. Silencing of rDNA occurs during early stages of Alzheimer's disease (AD) and may play a role in dementia. Moreover, aberrant...
Autores principales: | Kiryk, Anna, Sowodniok, Katharina, Kreiner, Grzegorz, Rodriguez-Parkitna, Jan, Sönmez, Aynur, Górkiewicz, Tomasz, Bierhoff, Holger, Wawrzyniak, Marcin, Janusz, Artur K., Liss, Birgit, Konopka, Witold, Schütz, Günther, Kaczmarek, Leszek, Parlato, Rosanna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823236/ https://www.ncbi.nlm.nih.gov/pubmed/24273493 http://dx.doi.org/10.3389/fncel.2013.00207 |
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