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Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies

Differentiation of foetal cardiomyocytes is accompanied by sequential actin isoform expression, i.e. down-regulation of the ‘embryonic’ alpha smooth muscle actin, followed by an up-regulation of alpha skeletal actin (αSKA) and a final predominant expression of alpha cardiac actin (αCA). Our objectiv...

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Detalles Bibliográficos
Autores principales: Driesen, Ronald B, Verheyen, Fons K, Debie, Wiel, Blaauw, Erik, Babiker, Fawzi A, Cornelussen, Richard NM, Ausma, Jannie, Lenders, Marie-Hélène, Borgers, Marcel, Chaponnier, Christine, Ramaekers, Frans C S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823406/
https://www.ncbi.nlm.nih.gov/pubmed/19538254
http://dx.doi.org/10.1111/j.1582-4934.2008.00523.x