Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases

Gain-of-function mutations in the genes encoding Janus kinases have been discovered in various haematologic diseases. Jaks are composed of a FERM domain, an SH2 domain, a pseudokinase domain and a kinase domain, and a complex interplay of the Jak domains is involved in regulation of catalytic activi...

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Detalles Bibliográficos
Autores principales: Haan, Claude, Behrmann, Iris, Haan, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823453/
https://www.ncbi.nlm.nih.gov/pubmed/20132407
http://dx.doi.org/10.1111/j.1582-4934.2010.01018.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823453/
https://www.ncbi.nlm.nih.gov/pubmed/20132407
http://dx.doi.org/10.1111/j.1582-4934.2010.01018.x

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