Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

Down-regulation of protein phosphatase 2A (PP2A) is thought to play a critical role in tau hyperphosphorylation in Alzheimer's disease (AD). In vitro phosphorylation of PP2A catalytic subunit at Y307 efficiently inactivates PP2A. A specific antibody against phosphorylated (p) PP2A (Y307) (PP2Ac...

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Detalles Bibliográficos
Autores principales: Liu, R, Zhou, X-W, Tanila, H, Bjorkdahl, C, Wang, J-Z, Guan, Z-Z, Cao, Y, Gustafsson, J-Å, Winblad, B, Pei, J-J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
In Focus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823485/
https://www.ncbi.nlm.nih.gov/pubmed/18208556
http://dx.doi.org/10.1111/j.1582-4934.2008.00249.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823485/
https://www.ncbi.nlm.nih.gov/pubmed/18208556
http://dx.doi.org/10.1111/j.1582-4934.2008.00249.x

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