Eicosanoid Profiling in an Orthotopic Model of Lung Cancer Progression by Mass Spectrometry Demonstrates Selective Production of Leukotrienes by Inflammatory Cells of the Microenvironment

Eicosanoids are bioactive lipid mediators derived from arachidonic acid(1) (AA), which is released by cytosolic phospholipase A(2) (cPLA(2)). AA is metabolized through three major pathways, cyclooxygenase (COX), lipoxygenase (LO) and cytochrome P450, to produce a family of eicosanoids, which individ...

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Detalles Bibliográficos
Autores principales: Poczobutt, Joanna M., Gijon, Miguel, Amin, Jay, Hanson, Dwight, Li, Howard, Walker, Deandra, Weiser-Evans, Mary, Lu, Xian, Murphy, Robert C., Nemenoff, Raphael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823604/
https://www.ncbi.nlm.nih.gov/pubmed/24244531
http://dx.doi.org/10.1371/journal.pone.0079633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823604/
https://www.ncbi.nlm.nih.gov/pubmed/24244531
http://dx.doi.org/10.1371/journal.pone.0079633

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