Intensive Mutagenesis of the Nisin Hinge Leads to the Rational Design of Enhanced Derivatives

Nisin A is the most extensively studied lantibiotic and has been used as a preservative by the food industry since 1953. This 34 amino acid peptide contains three dehydrated amino acids and five thioether rings. These rings, resulting from one lanthionine and four methyllanthionine bridges, confer t...

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Detalles Bibliográficos
Autores principales: Healy, Brian, Field, Des, O’Connor, Paula M., Hill, Colin, Cotter, Paul D., Ross, R. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823697/
https://www.ncbi.nlm.nih.gov/pubmed/24244524
http://dx.doi.org/10.1371/journal.pone.0079563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823697/
https://www.ncbi.nlm.nih.gov/pubmed/24244524
http://dx.doi.org/10.1371/journal.pone.0079563

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