A directional switch of integrin signaling and a new anti-thrombotic strategy

Integrins are critical in thrombosis and hemostasis(1). Antagonists of the platelet integrin α(IIb)β(3) are potent anti-thrombotic drugs, but also have the life-threatening adverse effect of bleeding(2,3). It is thus desirable to develop new antagonists that do not cause bleeding. Integrins transmit...

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Detalles Bibliográficos
Autores principales: Shen, Bo, Zhao, Xiaojuan, O’Brien, Kelly A., Stojanovic-Terpo, Aleksandra, Delaney, M. Keegan, Kim, Kyungho, Cho, Jaehyung, Lam, Stephen C.-T., Du, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823815/
https://www.ncbi.nlm.nih.gov/pubmed/24162846
http://dx.doi.org/10.1038/nature12613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823815/
https://www.ncbi.nlm.nih.gov/pubmed/24162846
http://dx.doi.org/10.1038/nature12613

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