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A directional switch of integrin signaling and a new anti-thrombotic strategy
Integrins are critical in thrombosis and hemostasis(1). Antagonists of the platelet integrin α(IIb)β(3) are potent anti-thrombotic drugs, but also have the life-threatening adverse effect of bleeding(2,3). It is thus desirable to develop new antagonists that do not cause bleeding. Integrins transmit...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823815/ https://www.ncbi.nlm.nih.gov/pubmed/24162846 http://dx.doi.org/10.1038/nature12613 |