Hrs Promotes Ubiquitination and Mediates Endosomal Trafficking of Smoothened in Drosophila Hedgehog Signaling

In Hedgehog (Hh) signaling, the seven-transmembrane protein Smoothened (Smo) acts as a signal transducer that is regulated by phosphorylation, ubiquitination, and cell surface accumulation. However, it is not clear how Smo cell surface accumulation and intracellular trafficking are regulated. Here,...

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Detalles Bibliográficos
Autores principales: Fan, Junkai, Jiang, Kai, Liu, Yajuan, Jia, Jianhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823941/
https://www.ncbi.nlm.nih.gov/pubmed/24244405
http://dx.doi.org/10.1371/journal.pone.0079021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823941/
https://www.ncbi.nlm.nih.gov/pubmed/24244405
http://dx.doi.org/10.1371/journal.pone.0079021

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