Downregulation of IFNG in CD4(+) T Cells in Lung Cancer through Hypermethylation: A Possible Mechanism of Tumor-Induced Immunosuppression

Tumor survival is significantly correlated with the immune response of patients. IFNG plays an important role in the tumor host response and decreased IFNG expression is often observed in lung cancer. Studies have shown that CpG island hypermethylation plays a critical role in transcriptional silenc...

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Detalles Bibliográficos
Autores principales: Wang, Fang, Xu, Jian, Zhu, Quan, Qin, Xuejun, Cao, Yan, Lou, Jiangfang, Xu, Yuqiao, Ke, Xing, Li, Qing, Xie, Erfu, Zhang, Lixia, Sun, Ruihong, Chen, Liang, Fang, Bingliang, Pan, Shiyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823966/
https://www.ncbi.nlm.nih.gov/pubmed/24244422
http://dx.doi.org/10.1371/journal.pone.0079064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823966/
https://www.ncbi.nlm.nih.gov/pubmed/24244422
http://dx.doi.org/10.1371/journal.pone.0079064

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