Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress

XFE progeroid syndrome, a disease of accelerated aging caused by deficiency in the DNA repair endonuclease XPF-ERCC1, is modeled by Ercc1 knockout and hypomorphic mice. Tissues and primary cells from these mice senesce prematurely, offering a unique opportunity to identify factors that regulate sene...

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Detalles Bibliográficos
Autores principales: Nidadavolu, Lolita S., Niedernhofer, Laura J., Khan, Saleem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824412/
https://www.ncbi.nlm.nih.gov/pubmed/23852002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824412/
https://www.ncbi.nlm.nih.gov/pubmed/23852002

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