Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death

Microtubule inhibiting agents (MIAs) characteristically induce phosphorylation of the major anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2 and Bcl-xL, and although this leads to Mcl-1 degradation, the role of Bcl-2/Bcl-xL phosphorylation in mitotic death has remained controversial. This is in part...

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Detalles Bibliográficos
Autores principales: Eichhorn, J M, Sakurikar, N, Alford, S E, Chu, R, Chambers, T C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824670/
https://www.ncbi.nlm.nih.gov/pubmed/24091677
http://dx.doi.org/10.1038/cddis.2013.360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824670/
https://www.ncbi.nlm.nih.gov/pubmed/24091677
http://dx.doi.org/10.1038/cddis.2013.360

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