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CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia

Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease modeling and regenerative medicine approaches in humans. The aim of our study was to create an in vitro ‘patient-specific cell-based system' that could facilitate the screening of new therapeutic...

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Detalles Bibliográficos
Autores principales: Di Pasquale, E, Lodola, F, Miragoli, M, Denegri, M, Avelino-Cruz, J E, Buonocore, M, Nakahama, H, Portararo, P, Bloise, R, Napolitano, C, Condorelli, G, Priori, S G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824678/
https://www.ncbi.nlm.nih.gov/pubmed/24113177
http://dx.doi.org/10.1038/cddis.2013.369