Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity

The receptor tyrosine kinase Met and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas the deregulation of Met signaling is associated with tumorigenesis. While ligand-activated Met promotes survival, caspase-dependent generation of the p40 Met fragment leads...

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Detalles Bibliográficos
Autores principales: Lefebvre, J, Muharram, G, Leroy, C, Kherrouche, Z, Montagne, R, Ichim, G, Tauszig-Delamasure, S, Chotteau-Lelievre, A, Brenner, C, Mehlen, P, Tulasne, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824686/
https://www.ncbi.nlm.nih.gov/pubmed/24136235
http://dx.doi.org/10.1038/cddis.2013.377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824686/
https://www.ncbi.nlm.nih.gov/pubmed/24136235
http://dx.doi.org/10.1038/cddis.2013.377

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