p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs

Mad2 is a key component of the spindle assembly checkpoint (SAC) that delays the onset of anaphase until all kinetochores are attached to the spindle. It binds to Cdc20 and prevents it from promoting destruction of an anaphase inhibitor, Securin. Previously, we showed that a Mad2-binding protein, p3...

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Detalles Bibliográficos
Autores principales: Habu, Toshiyuki, Matsumoto, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824705/
https://www.ncbi.nlm.nih.gov/pubmed/24255856
http://dx.doi.org/10.1186/2193-1801-2-562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824705/
https://www.ncbi.nlm.nih.gov/pubmed/24255856
http://dx.doi.org/10.1186/2193-1801-2-562

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