Glutathione Depletion by L-Buthionine-S,R-Sulfoximine Induces Apoptosis of Cardiomyocytes through Activation of PKC-δ

In the present study, we investigated the effect of intracellular glutathione (GSH) depletion in heart-derived H9c2 cells and its mechanism. L-buthionine-S,R-sulfoximine (BSO) induced the depletion of cellular GSH, and BSO-induced reactive oxygen species (ROS) production was inhibited by glutathione...

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Detalles Bibliográficos
Autores principales: Kim, Young-Ae, Kim, Mi-Young, Jung, Yi-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825199/
https://www.ncbi.nlm.nih.gov/pubmed/24244823
http://dx.doi.org/10.4062/biomolther.2013.065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825199/
https://www.ncbi.nlm.nih.gov/pubmed/24244823
http://dx.doi.org/10.4062/biomolther.2013.065

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