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Structural insights into H(+)-coupled multidrug extrusion by a MATE transporter

Multidrug and toxic compound extrusion (MATE) transporters contribute to multidrug resistance by coupling the efflux of drugs to the influx of Na(+) or H(+). Known structures of Na(+)-coupled, extracellular-facing MATE transporters from the NorM subfamily revealed twelve membrane-spanning segments r...

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Detalles Bibliográficos
Autores principales: Lu, Min, Radchenko, Martha, Symersky, Jindrich, Nie, Rongxin, Guo, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825517/
https://www.ncbi.nlm.nih.gov/pubmed/24141706
http://dx.doi.org/10.1038/nsmb.2687