Getting by with a little help from the right CD4(+) T cells

Tumor infiltration by effector cells is essential for the efficacy of T cell-based immunotherapeutic approaches against brain malignancies. We found that tumor-associated antigen (TAA)-specific CD8(+) T cells are optimally recruited to neoplastic lesions when co-administered with T(H)1 polarized CD4...

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Detalles Bibliográficos
Autores principales: Hoepner, Sabine, Walker, Paul R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825730/
https://www.ncbi.nlm.nih.gov/pubmed/24244904
http://dx.doi.org/10.4161/onci.25772
Descripción
Sumario:Tumor infiltration by effector cells is essential for the efficacy of T cell-based immunotherapeutic approaches against brain malignancies. We found that tumor-associated antigen (TAA)-specific CD8(+) T cells are optimally recruited to neoplastic lesions when co-administered with T(H)1 polarized CD4(+) T cells that are also TAA-specific. However, in vitro T(H)1 polarization is not required for the long-term therapeutic efficacy of the combined transfer of CD4(+) and CD8(+) T cells.

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