Getting by with a little help from the right CD4(+) T cells

Tumor infiltration by effector cells is essential for the efficacy of T cell-based immunotherapeutic approaches against brain malignancies. We found that tumor-associated antigen (TAA)-specific CD8(+) T cells are optimally recruited to neoplastic lesions when co-administered with T(H)1 polarized CD4...

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Detalles Bibliográficos
Autores principales: Hoepner, Sabine, Walker, Paul R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825730/
https://www.ncbi.nlm.nih.gov/pubmed/24244904
http://dx.doi.org/10.4161/onci.25772
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author Hoepner, Sabine
Walker, Paul R
author_facet Hoepner, Sabine
Walker, Paul R
author_sort Hoepner, Sabine
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description Tumor infiltration by effector cells is essential for the efficacy of T cell-based immunotherapeutic approaches against brain malignancies. We found that tumor-associated antigen (TAA)-specific CD8(+) T cells are optimally recruited to neoplastic lesions when co-administered with T(H)1 polarized CD4(+) T cells that are also TAA-specific. However, in vitro T(H)1 polarization is not required for the long-term therapeutic efficacy of the combined transfer of CD4(+) and CD8(+) T cells.
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spelling pubmed-38257302013-11-15 Getting by with a little help from the right CD4(+) T cells Hoepner, Sabine Walker, Paul R Oncoimmunology Author's View Tumor infiltration by effector cells is essential for the efficacy of T cell-based immunotherapeutic approaches against brain malignancies. We found that tumor-associated antigen (TAA)-specific CD8(+) T cells are optimally recruited to neoplastic lesions when co-administered with T(H)1 polarized CD4(+) T cells that are also TAA-specific. However, in vitro T(H)1 polarization is not required for the long-term therapeutic efficacy of the combined transfer of CD4(+) and CD8(+) T cells. Landes Bioscience 2013-09-01 2013-07-29 /pmc/articles/PMC3825730/ /pubmed/24244904 http://dx.doi.org/10.4161/onci.25772 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Hoepner, Sabine
Walker, Paul R
Getting by with a little help from the right CD4(+) T cells
title Getting by with a little help from the right CD4(+) T cells
title_full Getting by with a little help from the right CD4(+) T cells
title_fullStr Getting by with a little help from the right CD4(+) T cells
title_full_unstemmed Getting by with a little help from the right CD4(+) T cells
title_short Getting by with a little help from the right CD4(+) T cells
title_sort getting by with a little help from the right cd4(+) t cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825730/
https://www.ncbi.nlm.nih.gov/pubmed/24244904
http://dx.doi.org/10.4161/onci.25772
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