Cargando…
Many human accelerated regions are developmental enhancers
The genetic changes underlying the dramatic differences in form and function between humans and other primates are largely unknown, although it is clear that gene regulatory changes play an important role. To identify regulatory sequences with potentially human-specific functions, we and others used...
Autores principales: | Capra, John A., Erwin, Genevieve D., McKinsey, Gabriel, Rubenstein, John L. R., Pollard, Katherine S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826498/ https://www.ncbi.nlm.nih.gov/pubmed/24218637 http://dx.doi.org/10.1098/rstb.2013.0025 |
Ejemplares similares
-
Disruptions in a cluster of computationally identified enhancers near FOXC1 and GMDS may influence brain development
por: Haliburton, Genevieve D. E., et al.
Publicado: (2015) -
Integrating Diverse Datasets Improves Developmental Enhancer Prediction
por: Erwin, Genevieve D., et al.
Publicado: (2014) -
Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons
por: McGregor, Matthew M., et al.
Publicado: (2019) -
Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor
por: Holloway, Alisha K., et al.
Publicado: (2016) -
Developmental Loci Harbor Clusters of Accelerated Regions That Evolved Independently in Ape Lineages
por: Kostka, Dennis, et al.
Publicado: (2018)