Single dose of Glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses

BACKGROUND: Herpes simplex virus type-1(HSV-1) and HSV-2 are important human pathogens that cause significant ocular and urogenital complications, respectively. We have previously shown that HSV-1 virions lacking glycoprotein K (gK) are unable to enter into neurons via synaptic axonal membranes and...

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Detalles Bibliográficos
Autores principales: Iyer, Arun V, Pahar, Bapi, Chouljenko, Vladimir N, Walker, Jason D, Stanfield, Brent, Kousoulas, Konstantin G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826548/
https://www.ncbi.nlm.nih.gov/pubmed/24165088
http://dx.doi.org/10.1186/1743-422X-10-317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826548/
https://www.ncbi.nlm.nih.gov/pubmed/24165088
http://dx.doi.org/10.1186/1743-422X-10-317

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