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Single dose of Glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses
BACKGROUND: Herpes simplex virus type-1(HSV-1) and HSV-2 are important human pathogens that cause significant ocular and urogenital complications, respectively. We have previously shown that HSV-1 virions lacking glycoprotein K (gK) are unable to enter into neurons via synaptic axonal membranes and...
Autores principales: | Iyer, Arun V, Pahar, Bapi, Chouljenko, Vladimir N, Walker, Jason D, Stanfield, Brent, Kousoulas, Konstantin G |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826548/ https://www.ncbi.nlm.nih.gov/pubmed/24165088 http://dx.doi.org/10.1186/1743-422X-10-317 |
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