Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase

Understanding the substrate recognition mechanism of γ-secretase is a key step for establishing substrate-specific inhibition of amyloid β-protein (Aβ) production. However, it is widely believed that γ-secretase is a promiscuous protease and that its substrate-specific inhibition is elusive. Here we...

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Detalles Bibliográficos
Autores principales: Funamoto, Satoru, Sasaki, Toru, Ishihara, Seiko, Nobuhara, Mika, Nakano, Masaki, Watanabe-Takahashi, Miho, Saito, Takashi, Kakuda, Nobuto, Miyasaka, Tomohiro, Nishikawa, Kiyotaka, Saido, Takaomi C., Ihara, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826621/
https://www.ncbi.nlm.nih.gov/pubmed/24108142
http://dx.doi.org/10.1038/ncomms3529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826621/
https://www.ncbi.nlm.nih.gov/pubmed/24108142
http://dx.doi.org/10.1038/ncomms3529

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