Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans

Obese individuals often have increased appetite despite normal plasma levels of the main orexigenic hormone ghrelin. Here we show that ghrelin degradation in the plasma is inhibited by ghrelin-reactive IgG immunoglobulins, which display increased binding affinity to ghrelin in obese patients and mic...

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Detalles Bibliográficos
Autores principales: Takagi, Kuniko, Legrand, Romain, Asakawa, Akihiro, Amitani, Haruka, François, Marie, Tennoune, Naouel, Coëffier, Moïse, Claeyssens, Sophie, do Rego, Jean-Claude, Déchelotte, Pierre, Inui, Akio, Fetissov, Sergueï O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826639/
https://www.ncbi.nlm.nih.gov/pubmed/24158035
http://dx.doi.org/10.1038/ncomms3685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826639/
https://www.ncbi.nlm.nih.gov/pubmed/24158035
http://dx.doi.org/10.1038/ncomms3685

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