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Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans
Obese individuals often have increased appetite despite normal plasma levels of the main orexigenic hormone ghrelin. Here we show that ghrelin degradation in the plasma is inhibited by ghrelin-reactive IgG immunoglobulins, which display increased binding affinity to ghrelin in obese patients and mic...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826639/ https://www.ncbi.nlm.nih.gov/pubmed/24158035 http://dx.doi.org/10.1038/ncomms3685 |