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Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows
Zinc-finger nickases (ZFNickases) are a type of programmable nuclease that can be engineered from zinc-finger nucleases to induce site-specific single-strand breaks or nicks in genomic DNA, which result in homology-directed repair. Although zinc-finger nuclease-mediated gene disruption has been demo...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826644/ https://www.ncbi.nlm.nih.gov/pubmed/24121612 http://dx.doi.org/10.1038/ncomms3565 |