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Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows

Zinc-finger nickases (ZFNickases) are a type of programmable nuclease that can be engineered from zinc-finger nucleases to induce site-specific single-strand breaks or nicks in genomic DNA, which result in homology-directed repair. Although zinc-finger nuclease-mediated gene disruption has been demo...

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Detalles Bibliográficos
Autores principales:	Liu, Xu, Wang, Yongsheng, Guo, Wenjiang, Chang, Bohao, Liu, Jun, Guo, Zekun, Quan, Fusheng, Zhang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826644/ https://www.ncbi.nlm.nih.gov/pubmed/24121612 http://dx.doi.org/10.1038/ncomms3565

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