Cargando…
Functional Analysis of a Breast Cancer-Associated FGFR2 Single Nucleotide Polymorphism Using Zinc Finger Mediated Genome Editing
Genome wide association studies have identified single nucleotide polymorphisms (SNP) within fibroblast growth factor receptor 2 (FGFR2) as one of the highest ranking risk alleles in terms of development of breast cancer. The potential effect of these SNPs, in intron two, was postulated to be due to...
Autores principales: | Robbez-Masson, Luisa J., Bödör, Csaba, Jones, J. Louise, Hurst, Helen C., Fitzgibbon, Jude, Hart, Ian R., Grose, Richard P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827080/ https://www.ncbi.nlm.nih.gov/pubmed/24265722 http://dx.doi.org/10.1371/journal.pone.0078839 |
Ejemplares similares
-
Retrotransposons shape species-specific embryonic stem cell gene expression
por: Robbez-Masson, Luisa, et al.
Publicado: (2015) -
Fibroblast Growth Factor 22 Is Not Essential for Skin Development and Repair but Plays a Role in Tumorigenesis
por: Jarosz, Monika, et al.
Publicado: (2012) -
Genome editing in plants via designed zinc finger nucleases
por: Petolino, Joseph F.
Publicado: (2015) -
Diversifying the structure of zinc finger nucleases for high-precision genome editing
por: Paschon, David E., et al.
Publicado: (2019) -
Five zinc finger protein 350 single nucleotide polymorphisms and the risks of breast cancer: a meta-analysis
por: Zeng, Yu Fan, et al.
Publicado: (2017)