Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis

The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been implicated in mTORC1 activation, little is known about how mTORC2 is regulated. H...

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Detalles Bibliográficos
Autores principales: Liu, Pengda, Gan, Wenjian, Inuzuka, Hiroyuki, Lazorchak, Adam S, Gao, Daming, Arojo, Omotooke, Liu, Dou, Wan, Lixin, Zhai, Bo, Yu, Yonghao, Yuan, Min, Kim, Byeong Mo, Shaik, Shavali, Menon, Suchithra, Gygi, Steven P., Lee, Tae Ho, Asara, John M, Manning, Brendan D., Blenis, John, Su, Bing, Wei, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827117/
https://www.ncbi.nlm.nih.gov/pubmed/24161930
http://dx.doi.org/10.1038/ncb2860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827117/
https://www.ncbi.nlm.nih.gov/pubmed/24161930
http://dx.doi.org/10.1038/ncb2860

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