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Denatured State Structural Property Determines Protein Stabilization by Macromolecular Crowding: A Thermodynamic and Structural Approach
Understanding of protein structure and stability gained to date has been acquired through investigations made under dilute conditions where total macromolecular concentration never surpasses 10 g l(−1). However, biological macromolecules are known to evolve and function under crowded intracellular e...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827121/ https://www.ncbi.nlm.nih.gov/pubmed/24265729 http://dx.doi.org/10.1371/journal.pone.0078936 |