Dose-Finding Based on Bivariate Efficacy-Toxicity Outcome Using Archimedean Copula

In dose-finding clinical study, it is common that multiple endpoints are of interest. For instance, efficacy and toxicity endpoints are both primary in clinical trials. In this article, we propose a joint model for correlated efficacy-toxicity outcome constructed with Archimedean Copula, and extend...

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Detalles Bibliográficos
Autores principales: Tao, Yuxi, Liu, Junlin, Li, Zhihui, Lin, Jinguan, Lu, Tao, Yan, Fangrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827126/
https://www.ncbi.nlm.nih.gov/pubmed/24265719
http://dx.doi.org/10.1371/journal.pone.0078805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827126/
https://www.ncbi.nlm.nih.gov/pubmed/24265719
http://dx.doi.org/10.1371/journal.pone.0078805

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