Cargando…

A New Mutation of the Atoh1 Gene in Mice with Normal Life Span Allows Analysis of Inner Ear and Cerebellar Phenotype in Aging

Atoh1 is a transcription factor that regulates neural development in multiple tissues and is conserved among species. Prior mouse models of Atoh1, though effective and important in the evolution of our understanding of the gene, have been limited by perinatal lethality. Here we describe a novel poin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sheykholeslami, Kianoush, Thimmappa, Vikrum, Nava, Casey, Bai, Xiaohui, Yu, Heping, Zheng, Tihua, Zhang, Zhaoqiang, Li, Sheng Li, Liu, Shuqing, Zheng, Qing Yin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827170/ https://www.ncbi.nlm.nih.gov/pubmed/24265785 http://dx.doi.org/10.1371/journal.pone.0079791

Ejemplares similares

The Repression of Atoh1 by Neurogenin1 during Inner Ear Development
por: Gálvez, Héctor, et al.
Publicado: (2017)

Identification of genes concordantly expressed with Atoh1 during inner ear development
por: Yoon, Heejei, et al.
Publicado: (2011)

Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells
por: Zhang, Yong-Li, et al.
Publicado: (2022)

The Prosensory Function of Sox2 in the Chicken Inner Ear Relies on the Direct Regulation of Atoh1
por: Neves, Joana, et al.
Publicado: (2012)

The proper timing of Atoh1 expression is pivotal for hair cell subtype differentiation and the establishment of inner ear function
por: You, Dan, et al.
Publicado: (2023)

Hearing Loss in Id1(−/−); Id3(+/−) and Id1(+/−); Id3(−/−) Mice Is Associated With a High Incidence of Middle Ear Infection (Otitis Media)
por: Zheng, Qingyin, et al.
Publicado: (2021)

A Rare Case of Splenic Marginal Zone B-Cell Lymphoma Mimicking Relapsing Polychondritis of the Ear
por: Huang, Gary J., et al.
Publicado: (2014)

Generation of Atoh1-rtTA transgenic mice: a tool for inducible gene expression in hair cells of the inner ear
por: Cox, Brandon C., et al.
Publicado: (2014)

Celastrol enhances Atoh1 expression in inner ear stem cells and promotes their differentiation into functional auditory neuronal-like cells
por: Han, Zhao, et al.
Publicado: (2018)

Differential regulation of mammalian and avian ATOH1 by E2F1 and its implication for hair cell regeneration in the inner ear
por: Gómez-Dorado, Miriam, et al.
Publicado: (2021)

Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish
por: Ezhkova, Diana, et al.
Publicado: (2023)

Single dose intralesional doxycycline foam infusion promotes bone growth and resolution of an odontoid aneurysmal bone cyst
por: Omosor, Emmanuel, et al.
Publicado: (2023)

Nanocarriers for Inner Ear Disease Therapy
por: Xu, Xiaoxiang, et al.
Publicado: (2021)

Inner Ear
por: Arnold, Andreas, et al.
Publicado: (2010)

In Vivo Generation of Immature Inner Hair Cells in Neonatal Mouse Cochleae by Ectopic Atoh1 Expression
por: Liu, Zhiyong, et al.
Publicado: (2014)

Atoh8 in Development and Disease
por: Divvela, Satya Srirama Karthik, et al.
Publicado: (2022)

Proteomics and the Inner Ear
por: Thalmann, Isolde
Publicado: (2001)

Role of Inner Ear Macrophages and Autoimmune/Autoinflammatory Mechanisms in the Pathophysiology of Inner Ear Disease
por: Miwa, Toru, et al.
Publicado: (2022)

Inner Ear Therapeutics: An Overview of Middle Ear Delivery
por: Patel, Jaimin, et al.
Publicado: (2019)

Inner ear disturbances related to middle ear inflammation
por: Sone, Michihiko
Publicado: (2017)

Autophagy in the Vertebrate Inner Ear
por: Magariños, Marta, et al.
Publicado: (2017)

Effects of Glucocorticoids on the Inner Ear
por: Takeda, Taizo, et al.
Publicado: (2021)

Editorial: Neuroimmunology of the Inner Ear
por: Perin, Paola, et al.
Publicado: (2021)

Editorial: Autoinflammation of the inner ear
por: Nakanishi, Hiroshi, et al.
Publicado: (2022)

Conditional loss of Engrailed1/2 in Atoh1‐derived excitatory cerebellar nuclear neurons impairs eupneic respiration in mice
por: Taylor, Angela P., et al.
Publicado: (2022)

Single-Cell Sequencing Applications in the Inner Ear
por: Wu, Mingxuan, et al.
Publicado: (2021)

Fossil basicranium clarifies the origin of the avian central nervous system and inner ear
por: Chiappe, Luis M., et al.
Publicado: (2022)

The Role of Atoh1 in Mucous Cell Metaplasia
por: Nakamura, Yoshihisa, et al.
Publicado: (2012)

Melatonin reduces radiation damage in inner ear
por: Chen, Ting, et al.
Publicado: (2021)

Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo
por: Shu, Yilai, et al.
Publicado: (2016)

What's new in otology--the inner ear.
por: Shepperd, H. W.
Publicado: (1966)

Feedback System Protects Inner Ear
por: Robinson, Richard
Publicado: (2009)

Tricellular Tight Junctions in the Inner Ear
por: Kitajiri, Shin-ichiro, et al.
Publicado: (2016)

CBCT of Osteogenesis Imperfecta of the Inner Ear
por: Gillardin, Patrick, et al.
Publicado: (2015)

Inner ear delivery: Challenges and opportunities
por: Szeto, Betsy, et al.
Publicado: (2019)

Tsukushi is essential for the development of the inner ear
por: Miwa, Toru, et al.
Publicado: (2020)

Analysis of Pharmacokinetics in the Cochlea of the Inner Ear
por: Sawamura, Seishiro, et al.
Publicado: (2021)

Application of Nanomedicine in Inner Ear Diseases
por: Lin, Qianyu, et al.
Publicado: (2022)

Metabolomic Studies in Inner Ear Pathologies
por: Boullaud, Luc, et al.
Publicado: (2022)

Nanoparticles for the Treatment of Inner Ear Infections
por: Gheorghe, Dan Cristian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ga6635l893rvqd6ftddit6g5ob