Discovery and Characterization of a Novel Cyclic Peptide That Effectively Inhibits Ephrin Binding to the EphA4 Receptor and Displays Anti-Angiogenesis Activity

The EphA4 receptor tyrosine kinase regulates a variety of physiological and pathological processes during neural development and the formation of tumor blood vessels; thus, it represents a new and promising therapeutic target. We used a combination of phage peptide display and computer modeling/dock...

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Detalles Bibliográficos
Autores principales: Han, Xiaofeng, Xu, Yan, Yang, Yilei, Xi, Jingle, Tian, Wang, Duggineni, Srinivas, Huang, Ziwei, An, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827205/
https://www.ncbi.nlm.nih.gov/pubmed/24265799
http://dx.doi.org/10.1371/journal.pone.0080183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827205/
https://www.ncbi.nlm.nih.gov/pubmed/24265799
http://dx.doi.org/10.1371/journal.pone.0080183

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