Molecular Dynamics Analysis of a Novel β3 Pro189Ser Mutation in a Patient with Glanzmann Thrombasthenia Differentially Affecting αIIbβ3 and αvβ3 Expression

Mutations in ITGA2B and ITGB3 cause Glanzmann thrombasthenia, an inherited bleeding disorder in which platelets fail to aggregate when stimulated. Whereas an absence of expression or qualitative defects of αIIbβ3 mainly affect platelets and megakaryocytes, αvβ3 has a widespread tissue distribution....

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Detalles Bibliográficos
Autores principales: Laguerre, Michel, Sabi, Essa, Daly, Martina, Stockley, Jacqueline, Nurden, Paquita, Pillois, Xavier, Nurden, Alan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827234/
https://www.ncbi.nlm.nih.gov/pubmed/24236036
http://dx.doi.org/10.1371/journal.pone.0078683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827234/
https://www.ncbi.nlm.nih.gov/pubmed/24236036
http://dx.doi.org/10.1371/journal.pone.0078683

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