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An Ultrasensitive High Throughput Screen for DNA Methyltransferase 1-Targeted Molecular Probes
DNA methyltransferase 1 (DNMT1) is the enzyme most responsible for epigenetic modification of human DNA and the intended target of approved cancer drugs such as 5-aza-cytidine and 5-aza-2′-deoxycytidine. 5-aza nucleosides have complex mechanisms of action that require incorporation into DNA, and cov...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827244/ https://www.ncbi.nlm.nih.gov/pubmed/24236046 http://dx.doi.org/10.1371/journal.pone.0078752 |