HER2 Phosphorylates and Destabilizes Pro-Apoptotic PUMA, Leading to Antagonized Apoptosis in Cancer Cells

HER2 is overexpressed in 15–20% of breast cancers. HER2 overexpression is known to reduce apoptosis but the underlying mechanisms for this association remain unclear. To elucidate the mechanisms for HER2-mediated survival, we investigated the relationship between HER2 and p53 upregulated modulator o...

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Detalles Bibliográficos
Autores principales: Carpenter, Richard L., Han, Woody, Paw, Ivy, Lo, Hui-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827261/
https://www.ncbi.nlm.nih.gov/pubmed/24236056
http://dx.doi.org/10.1371/journal.pone.0078836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827261/
https://www.ncbi.nlm.nih.gov/pubmed/24236056
http://dx.doi.org/10.1371/journal.pone.0078836

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