Cargando…

Role of Tumor Necrosis Factor-α in the Human Systemic Endotoxin-Induced Transcriptome

TNFα has been implicated in the pathogenesis of various inflammatory diseases. Different strategies to inhibit TNFα in patients with sepsis and chronic inflammatory conditions have shown contrasting outcomes. Although TNFα inhibitors are widely used in clinical practice, the impact of TNFα antagonis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scicluna, Brendon P., van 't Veer, Cornelis, Nieuwdorp, Max, Felsmann, Karen, Wlotzka, Britta, Stroes, Erik S. G., van der Poll, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827317/ https://www.ncbi.nlm.nih.gov/pubmed/24236088 http://dx.doi.org/10.1371/journal.pone.0079051

Ejemplares similares

DNA Methyltransferase 3b in Myeloid Cells Does Not Affect the Acute Immune Response in the Airways during Pseudomonas Pneumonia
por: Qin, Wanhai, et al.
Publicado: (2022)

Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling
por: Scicluna, Brendon P, et al.
Publicado: (2012)

Myeloid miR-155 plays a limited role in antibacterial defense during Klebsiella-derived pneumosepsis and is dispensable for lipopolysaccharide- or Klebsiella-induced inflammation in mice
por: Qin, Wanhai, et al.
Publicado: (2023)

The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection
por: Qin, Wanhai, et al.
Publicado: (2021)

Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection
por: Qin, Wanhai, et al.
Publicado: (2021)

Role of Myeloid Tet Methylcytosine Dioxygenase 2 in Pulmonary and Peritoneal Inflammation Induced by Lipopolysaccharide and Peritonitis Induced by Escherichia coli
por: Qin, Wanhai, et al.
Publicado: (2021)

Transcriptional changes in alveolar macrophages from adults with asthma after allergen challenge
por: Yang, Jack, et al.
Publicado: (2021)

The Long Non-Coding Antisense RNA JHDM1D-AS1 Regulates Inflammatory Responses in Human Monocytes
por: Malmström, Erik, et al.
Publicado: (2022)

Genetic signature related to heme-hemoglobin metabolism pathway in sepsis secondary to pneumonia
por: Leite, Giuseppe Gianini Figuerêido, et al.
Publicado: (2019)

Role of tissue factor in the procoagulant and antibacterial effects of human adipose-derived mesenchymal stem cells during pneumosepsis in mice
por: Perlee, Desirée, et al.
Publicado: (2019)

A Transcriptomic Biomarker to Quantify Systemic Inflammation in Sepsis — A Prospective Multicenter Phase II Diagnostic Study
por: Bauer, Michael, et al.
Publicado: (2016)

Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms
por: Sipka, S., et al.
Publicado: (1995)

Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation
por: Qin, Wanhai, et al.
Publicado: (2022)

Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice
por: Ding, Chao, et al.
Publicado: (2019)

Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis
por: Ding, Chao, et al.
Publicado: (2019)

Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity
Publicado: (1988)

Glucocorticoid-mediated inhibition of endotoxin-induced intratumor tumor necrosis factor production and tumor hemorrhagic necrosis and regression
Publicado: (1989)

Cellular mechanisms of acute septic cardiomyopathy: cardiodepressive profiles of endotoxin, tumor necrosis factor α and interleukin-1 in the cardiomyocyte
por: Müller-Werdan, U, et al.
Publicado: (1997)

Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study
por: Schouten, Marcel, et al.
Publicado: (2010)

Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study
por: Schouten, Marcel, et al.
Publicado: (2012)

Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?
por: Uhel, Fabrice, et al.
Publicado: (2019)

Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis
por: van Vught, Lonneke A., et al.
Publicado: (2021)

HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis
por: Matsumoto, Hisatake, et al.
Publicado: (2021)

An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration
por: Brands, Xanthe, et al.
Publicado: (2021)

The structure function of the death domain of human IRAK-M
por: Du, Jiangfeng, et al.
Publicado: (2014)

C3a signaling is not involved in eosinophil migration during experimental allergic lung inflammation in mice
por: Yang, Jack, et al.
Publicado: (2019)

Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice
por: Meijer, Mariska T., et al.
Publicado: (2021)

Transcriptome-wide Analysis of Exosome Targets
por: Schneider, Claudia, et al.
Publicado: (2012)

Ignoring endotoxin
por: Van Epps, Heather L.
Publicado: (2006)

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock
Publicado: (1989)

Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients
por: Brands, Xanthe, et al.
Publicado: (2022)

Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia
por: Pereverzeva, Liza, et al.
Publicado: (2021)

THE ROLE OF EPINEPHRINE IN THE REACTIONS PRODUCED BY THE ENDOTOXINS OF GRAM-NEGATIVE BACTERIA : I. HEMORRHAGIC NECROSIS PRODUCED BY EPINEPHRINE IN THE SKIN OF ENDOTOXIN-TREATED RABBITS
por: Thomas, Lewis
Publicado: (1956)

Role of CD14 in a Mouse Model of Acute Lung Inflammation Induced by Different Lipopolysaccharide Chemotypes
por: Anas, Adam A., et al.
Publicado: (2010)

Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study
por: Uhel, Fabrice, et al.
Publicado: (2020)

Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia
por: Khan, Hina N., et al.
Publicado: (2019)

Human Adipose‐Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae
por: Perlee, Desiree, et al.
Publicado: (2019)

Glucose metabolism is upregulated in the mononuclear cell proteome during sepsis and supports endotoxin-tolerant cell function
por: Ferreira, Bianca Lima, et al.
Publicado: (2022)

Combined Transcriptome and Proteome Leukocyte’s Profiling Reveals Up-Regulated Module of Genes/Proteins Related to Low Density Neutrophils and Impaired Transcription and Translation Processes in Clinical Sepsis
por: Leite, Giuseppe Gianini Figueirêdo, et al.
Publicado: (2021)

The antitumor function of tumor necrosis factor (TNF) II. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma
Publicado: (1988)

Cannot write session to /tmp/vufind_sessions/sess_ni9tbonn89u8vi413ira5b56kf