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Computational Protein Design Quantifies Structural Constraints on Amino Acid Covariation
Amino acid covariation, where the identities of amino acids at different sequence positions are correlated, is a hallmark of naturally occurring proteins. This covariation can arise from multiple factors, including selective pressures for maintaining protein structure, requirements imposed by a spec...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828131/ https://www.ncbi.nlm.nih.gov/pubmed/24244128 http://dx.doi.org/10.1371/journal.pcbi.1003313 |