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Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes
Bacterial DsbA enzymes catalyze oxidative folding of virulence factors, and have been identified as targets for antivirulence drugs. However, DsbA enzymes characterized to date exhibit a wide spectrum of redox properties and divergent structural features compared to the prototypical DsbA enzyme of E...
Autores principales: | Kurth, Fabian, Rimmer, Kieran, Premkumar, Lakshmanane, Mohanty, Biswaranjan, Duprez, Wilko, Halili, Maria A., Shouldice, Stephen R., Heras, Begoña, Fairlie, David P., Scanlon, Martin J., Martin, Jennifer L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828196/ https://www.ncbi.nlm.nih.gov/pubmed/24244651 http://dx.doi.org/10.1371/journal.pone.0080210 |
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