Effects of Dantrolene Therapy on Disease Phenotype in Dystrophin Deficient mdx Mice

Dystrophin deficiency causes contraction-induced injury and damage to the muscle fiber, resulting in sustained increase in intracellular calcium levels, activation of calcium-dependent proteases and cell death. It is known that the Ryanodine receptor (RyR1) on the sarcoplasmic reticular (SR) membran...

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Detalles Bibliográficos
Autores principales: Quinn, James L, Huynh, Tony, Uaesoontrachoon, Kitipong, Tatem, Kathleen, Phadke, Aditi, Van der Meulen, Jack H, Yu, Qing, Nagaraju, Kannaboyina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828224/
https://www.ncbi.nlm.nih.gov/pubmed/24270550
http://dx.doi.org/10.1371/currents.md.e246cf493a7edb1669f42fb735936b46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828224/
https://www.ncbi.nlm.nih.gov/pubmed/24270550
http://dx.doi.org/10.1371/currents.md.e246cf493a7edb1669f42fb735936b46

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