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Decrease in Prosaposin in the Dystrophic mdx Mouse Brain
BACKGROUND: Duchenne muscular dystrophy caused by a mutation in the X-linked dystrophin gene induces metabolic and structural disorders in the brain. A lack of dystrophin in brain structures is involved in impaired cognitive function. Prosaposin (PS), a neurotrophic factor, is abundant in the choroi...
Autores principales: | Gao, Hui-ling, Li, Cheng, Nabeka, Hiroaki, Shimokawa, Tetsuya, Kobayashi, Naoto, Saito, Shouichiro, Wang, Zhan-You, Cao, Ya-ming, Matsuda, Seiji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828254/ https://www.ncbi.nlm.nih.gov/pubmed/24244600 http://dx.doi.org/10.1371/journal.pone.0080032 |
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