Cargando…

Pifithrin-μ, an Inhibitor of Heat-Shock Protein 70, Can Increase the Antitumor Effects of Hyperthermia Against Human Prostate Cancer Cells

Hyperthermia (HT) improves the efficacy of anti-cancer radiotherapy and chemotherapy. However, HT also inevitably evokes stress responses and increases the expression of heat-shock proteins (HSPs) in cancer cells. Among the HSPs, HSP70 is known as a pro-survival protein. In this study, we investigat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sekihara, Kazumasa, Harashima, Nanae, Tongu, Miki, Tamaki, Yukihisa, Uchida, Nobue, Inomata, Taisuke, Harada, Mamoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828328/ https://www.ncbi.nlm.nih.gov/pubmed/24244355 http://dx.doi.org/10.1371/journal.pone.0078772

Ejemplares similares

Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state
por: Tongu, Miki, et al.
Publicado: (2015)

Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia
por: Kaiser, M, et al.
Publicado: (2011)

Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells
por: McKeon, Aoife M., et al.
Publicado: (2016)

Correction: Griffith, D.M., et al. Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. Molecules 2016, 21, 949
por: McKeon, Aoife M., et al.
Publicado: (2016)

The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia
por: Fleiss, Bobbi, et al.
Publicado: (2015)

0356. Effect of the neuroprotective p53-inhibitor pifithrin-µ in a rodent cardiac arrest model
por: Springe, D, et al.
Publicado: (2014)

Short treatment time and excellent treatment outcome in accelerated hyperfractionated radiotherapy for T1 glottic cancer
por: Tamaki, Yukihisa, et al.
Publicado: (2015)

Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system
por: Harashima, Nanae, et al.
Publicado: (2014)

Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL
por: Hari, Yoko, et al.
Publicado: (2015)

HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression
por: Harashima, Nanae, et al.
Publicado: (2017)

Serine Proteinase Inhibitor 9 Can Be Recognized by Cytotoxic T Lymphocytes of Epithelial Cancer Patients
por: Tanaka, Koji, et al.
Publicado: (2002)

Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition
por: Tamaki, Hiroki, et al.
Publicado: (2014)

The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells
por: Zhang, Min, et al.
Publicado: (2015)

Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer
por: Tanino, Ryosuke, et al.
Publicado: (2018)

Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner
por: Zhang, Ping, et al.
Publicado: (2016)

The p53-inhibitor Pifithrin-α inhibits Firefly Luciferase activity in vivo and in vitro
por: Rocha, Sonia, et al.
Publicado: (2003)

Pro-apoptotic Effect of Pifithrin-α on Preimplantation Porcine In vitro Fertilized Embryo Development
por: Mulligan, Brendan, et al.
Publicado: (2012)

Contrasting effects of cyclophosphamide on anti‐CTL‐associated protein 4 blockade therapy in two mouse tumor models
por: Iida, Yuichi, et al.
Publicado: (2017)

Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke
por: Turcato, Flavia, et al.
Publicado: (2018)

Pifithrin-α ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation
por: Yuqiang, Chen, et al.
Publicado: (2022)

Identification of Cyclophilin B‐derived Peptides Capable of Inducing Histocompatibility Leukocyte Antigen‐A2‐restricted and Tumor‐specific Cytotoxic T Lymphocytes
por: Tamura, Mayumi, et al.
Publicado: (2001)

Usefulness of direct‐conversion flat‐panel detector system as a quality assurance tool for high‐dose‐rate (192)Ir source
por: Miyahara, Yoshinori, et al.
Publicado: (2015)

Antiproliferative Activity of Cinnamomum cassia Constituents and Effects of Pifithrin-Alpha on Their Apoptotic Signaling Pathways in Hep G2 Cells
por: Ng, Lean-Teik, et al.
Publicado: (2011)

Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes
por: Zhu, Jiawei, et al.
Publicado: (2020)

Neuroprotective effects of pifithrin-α against traumatic brain injury in the striatum through suppression of neuroinflammation, oxidative stress, autophagy, and apoptosis
por: Huang, Ya-Ni, et al.
Publicado: (2018)

Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy
por: Liu, Xiaoli, et al.
Publicado: (2020)

Drug- and/or trauma-induced hyperthermia? Characterization of HSP70 and myoglobin expression
por: Ondruschka, Benjamin, et al.
Publicado: (2018)

Antitumor effects of high-temperature hyperthermia on a glioma rat model
por: TAKAGI, HIDEFUMI, et al.
Publicado: (2014)

Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma
por: Le Fèvre, Raphaël, et al.
Publicado: (2017)

Antitumor Immunity Induction by Intracellular Hyperthermia Using Magnetite Cationic Liposomes
por: Yanase, Mitsugu, et al.
Publicado: (1998)

Malignant Hyperthermia during Thoracoscopic Pulmorrhaphy in a 70-Year-Old Man
por: Sakai, Michihiro, et al.
Publicado: (2014)

β-Elemene Promotes Apoptosis Induced by Hyperthermia via Inhibiting HSP70
por: Zhang, Cuiwei, et al.
Publicado: (2022)

Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70
por: Maruyama, Michihiro, et al.
Publicado: (1995)

Proposal of New Safety Limits for In Vivo Experiments of Magnetic Hyperthermia Antitumor Therapy
por: Herrero de la Parte, Borja, et al.
Publicado: (2022)

Concurrent Chemoradiotherapy with Docetaxel, Cisplatin, and 5-fluorouracil Improves Survival of Patients with Advanced Esophageal Cancer Compared with Conventional Concurrent Chemoradiotherapy with Cisplatin and 5-fluorouracil
por: Tamaki, Yukihisa, et al.
Publicado: (2018)

The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia
por: Finkel, Patrick, et al.
Publicado: (2016)

Bacterial Lipopolysaccharide Augments Febrile-Range Hyperthermia-Induced Heat Shock Protein 70 Expression and Extracellular Release in Human THP1 Cells
por: Tulapurkar, Mohan E., et al.
Publicado: (2015)

Effective impairment of myeloma cells and their progenitors by hyperthermia
por: Miki, Hirokazu, et al.
Publicado: (2017)

Cetuximab delivery and antitumor effects are enhanced by mild hyperthermia in a xenograft mouse model of pancreatic cancer
por: Miyamoto, Ryoichi, et al.
Publicado: (2016)

HSP70 Inhibition Leads to the Activation of Proteasomal System under Mild Hyperthermia Conditions in Young and Senescent Fibroblasts
por: Bozaykut, Perinur, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kd6b6pqo89ic53q52evspojskh