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Structural Features of the Regulatory ACT Domain of Phenylalanine Hydroxylase

Phenylalanine hydroxylase (PAH) catalyzes the conversion of L-Phe to L-Tyr. Defects in PAH activity, caused by mutations in the human gene, result in the autosomal recessively inherited disease hyperphenylalaninemia. PAH activity is regulated by multiple factors, including phosphorylation and ligand...

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Detalles Bibliográficos
Autores principales: Carluccio, Carla, Fraternali, Franca, Salvatore, Francesco, Fornili, Arianna, Zagari, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828330/
https://www.ncbi.nlm.nih.gov/pubmed/24244510
http://dx.doi.org/10.1371/journal.pone.0079482